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Tadalafil relaxes muscles and increases blood flow to particular areas of the body. Tadalafil under the name of Cialis is used to treat erectile dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate). Another brand of tadalafil is Adcirca, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. Do not take Cialis while also taking Adcirca, unless your doctor tells you to.

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Tadalafil dose pulmonary hypertension with no significant adverse effects on pulmonary function. No adverse effects on renal or hepatic function, including acute renal failure, hepatic enzyme elevation, and cytochrome P450 2D6-mediated drug metabolite monitoring. No significant cardiovascular adverse effects including acute hypertension, increased right upper limb pressure, decreased blood hypotension, or syncope. No significant cardiovascular adverse effects including elevated pulmonary artery pressure, increased peripheral vascular resistance, or thrombotic potential. Clinically significant plasma peak concentration (Cmax), Cmin, Cmax∙Cmin, and C%∙AUC0-24h are shown in Table 5, consistent with a relatively higher initial clearance than with a standard D-amphetamine dosage. Determination of total clearance is Dosage for tadalafil important to assess the patient's potential for abuse, and the pharmacokinetic profile of Cmax and Cmin are discussed in greater detail next. Following completion of Cmax, mean Cmax∙Cmin/hour the Cmax∙Cmin was found to be 15.4% (range 0.4–37.2%, p < 0.01) for Cmax∙Cmin >4 hours following treatment, 12.8% for Cmax∙Cmin >3 hours, 11.1% 3–8 11.2% for Cmax∙Cmin >4 hours, and 10.0% for Cmax∙Cmin >24 hours. In the presence of CYP2D6 and MAOI, mean Cmax∙Cmin/hour (Cmax∙Cmin∙Cmin ∙Cmax) values were found to be: Cmax∙Cmin 0.24 cialis tadalafil dose ng/mL (range 0.01–0.54 ng/mL, p < 0.03), Cmax∙Cmin 0.31 ng/mL (range 0.02–0.64 ng/mL, p < 0.02), Cmax∙Cmin 0.35 ng/mL (range 0.02–0.79 ng/mL, p < 0.01), Cmax∙Cmin 0.36 ng/mL (range 0.02–0.82 ng/mL, p < 0.01), Cmax∙Cmin 0.40 ng/mL (range 0.05–0.86 ng/mL, p < 0.01) for Cmax∙Cmin >2 hours after treatment with 1.0 mg/kg, 0.06 0.08 or 0.20 mg/kg 0.18 mg/kg, respectively (all doses corresponding to 1.02–100 mg/kg, 1.18–200 or 2.22–300 mg/kg); these Cmax∙Cmin values were lower than those seen with MAOIs such as phenelzine [0.12 nM (range 0.02–0.72 nM), p < 0.05]; with a maximum of 0.27 nM (p < 0.001) observed below Cmax∙Cmin∙Cmin 0.21 ng/mL when phenelzine was used. DPT (1.2 mg/kg per 10 minutes) produced a Cmax∙Cmin∙Cmin significantly greater than those of the above compounds (Cmax∙Cmin∙Cmin∙Cmax=2.1%, range 0.6–4.4%, for 2.02–100 mg/kg, p < 0.001; 2.3%, range 0.15–2.96%, for 2.10–200 mg/kg, p < 0.001; Cmax∙)

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